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KMID : 0391419960060020137
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Korean Journal of Lipidology
1996 Volume.6 No. 2 p.137 ~ p.146
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Effect of Dietary Iron and Selenium Levels on Lipid Levels of Rats Fed Cholesterol Diet
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Abstract
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The purpose of this study was to investigate the effect of dietary iron and selenium levels on iron, selenium, and lipid levels in growing rats fed adequate iron(35ppm), 2-fold iron(70ppm), 4-fold iron(140ppm), adequate selenium(0.05ppm), and
high
selenium(0.5ppm) diet added 0.4% cholesterol for 12 weeks. Feed intake and feed/gain of 2-fold iron group were higher than those of adequate and 4-fold iron group. there were no differences in hemoglobin and hematocrit across iron and selenium
diet
groups. Serum iron level was increased as the increment of iron intake. Serum cholesterol and (LDL+VLDL)-cholesterol levels were increased as the increment of iron intake and decreased as the selenium supplementation. There was no difference in
serum
triglyceride across iron and selenium diet groups. Liver iron and cholesterol levels were increased as the increment of iron intake and decreased as the selenium supplementation. According to this study, it could be suggested that the increment
of
dietary iron intake resulted in elevated lipid levels, especially cholesterol level in serum and liver in rats.However, the supplementation of dietary selenium resulted in lower lipid levels in serum and liver,. Theses finding indicated that in
high
iron intake must increase dietary selenium intake for prevention of cholesterol increments in rats.
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